The Properties of Poly-dl-alanyl Trypsin and Poly-dl-alanyl Chymotrypsin
نویسندگان
چکیده
منابع مشابه
Immunological and pharmacological characterization of poly-DL-alanyl-modified Erwinia carotovora L-asparaginase.
The covalent attachment of poly-DL-alanine peptides to lysyl residues on the surface of Erwinia carotovora L-asparaginase has produced a modified enzyme which is much less immunogenic in mice and demonstrates 100-fold longer plasma half-life in the rhesus monkey. Immunogenic responses towards both the immunoglobulin G (IgG) and immunoglobulin E (IgE) antibody subclasses were evaluated in C57BL ...
متن کاملEnzymatic hydrolysis of poly-DL-lysine.
The c o n d e n s a t io n o f racemic ly s in e to p o ly -D L ly s in e produces a great number o f d is t in guishable molecules. Following merely statistical reasoning the number o f “pure peptides“ — consisting of only one sort of enantiomers — should be extremely low. The hydrolysis of polyD L -ly s in e by pronase a n d t a k a -d ia s ta s e shows that a content of about 3% “pure“ pol...
متن کاملAntitumor properties of irinotecan-containing nanoparticles prepared using poly(DL-lactic acid) and poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol).
Irinotecan-containing nanoparticles (NP) were prepared by coprecipitation with addition of water to acetone solution of poly(DL-lactic acid), poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol) and irinotecan, and subsequent evaporation of organic solvent. NP were purified by gel filtration and used for experiments after condensation by evaporation. The obtained NP sh...
متن کاملContribution of Different Cell Types to the Genetic Control of Immune Responses as a Function of the Chemical Nature of the Polymeric Side Chains (poly-l-prolyl and Poly-dl-alanyl) of Synthetic Immunogens
Genetic regulation of immunological responsiveness was studied at the cellular level by comparing the limiting dilutions of immunocompetent cells from spleen, thymus, and bone marrow of high and low responders as a function of the poly-L-prolyl and poly-DL-alanyl side chains of two synthetic polypeptide immunogens. The spleens of immunized and unimmunized high responder DBA/1 mice were found to...
متن کاملChitosan/poly(DL,lactide-co-glycolide) scaffolds for tissue engineering.
Chitosan/poly(DL-lactide-co-glycolide) (Ch/DL PLG) composite scaffolds were fabricated by freeze-drying lyophilization, and were evaluated and compared for use as a bone regeneration scaffold through measurements of the compression mechanical properties of the porous scaffolds. Also, In vitro cell culture of Sprague-Dawley rat's osteoblasts were used to evaluate the phenotype expression of cell...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1962
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(19)70839-4